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In SLE, IFN-I production originates from dendritic cells, neutrophils, and monocytes/macrophages ( Figure 2 IFN-I-induced endothelial cell damage and repair-imbalance accelerate atherosclerosis ( Concurrently, IFN- creates anti-angiogenic microenvironments via IL-1 pathway dysregulation (reduced IL-1/1/1R1

The advent of GLP-1 agonists like tirzepatide and semaglutide is changing that calculus, offering non-surgical weight reduction comparable to bariatric surgery in some cases

So, the smart move is to use this time to really dial in your nutrition and make healthy habits second nature

Low end (~100200 mcg/day): ~23 vials Mid (~300600 mcg/day): ~46 vials High (up to 900 mcg/day): ~810 vials Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 12 weeks (1 daily): ~84 syringes 12 weeks (3 daily): ~252 syringes Bacteriostatic Water (10 mL bottles) Use ~3.0 mL per 10 mg vial for reconstitution