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The effective semaglutide dose range in this paradigm (0.010.1 mg/kg for males, 0.030.1 mg/kg for females) is consistent with doses reported to reduce alcohol self-administration and intake (0.0003-0.01 mg/kg) in rodent and nonhuman primate models (0.0030.01 mg/kg
Retatrutide targets three receptors, adding GIP (enhanced insulin response) and glucagon (increased energy expenditure and fat oxidation)
Wegovy if prescribed for cardiovascular risk reduction in adults with obesity/overweight + established heart disease
Trial data have shown weight reductions of up to approximately 22% in clinical studies
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