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Innovative delivery strategies to overcome specific barriers The treatment of glioblastoma (GBM) has long been hindered by the BBB and the severely hypoxic TME [246]

Interestingly, ALS and frontotemporal dementia (FTD) are closely related conditions and often share both genetic and disease mechanisms, especially in people with C9ORF72 mutations suggesting they may be part of the same disease spectrum (Parobkova and Matej, 2021)

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