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Potential areas of expansion include: Cardiovascular outcomes: A dedicated CVOT, if not already required as a post-marketing commitment, would evaluate whether orforglipron reduces MACE in patients with established cardiovascular disease or high cardiovascular risk, following the precedent set by the SELECT trial for semaglutide

Coenzyme Q10 (CoQ10), which supports mitochondrial health and indirectly stabilizes telomere length through reduced oxidative stress

Semaglutide 10mg is a widely studied GLP-1 receptor agonist used in research focused on metabolic regulation, appetite signaling, and glucose control

Guidance on lifestyle changes like diet and exercise that complement the treatment for long-term success