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Inhibitors of USP14 are being developed to enhance the degradation of oncogenic proteins

Collectively, these design principles establish a biointelligent framework for HAGSH scaffold development, where structural adaptability, biochemical responsiveness, and polymer network precision converge to create mechanically robust yet biologically dynamic systems ideally suited for redox-regulated wound repair

Although preclinical studies have illustrated that pure nanotherapeutics possess some therapeutic functions, challenges still remain in their low accumulation at the targeted areas and easy leakage, which may cause therapeutic inefficiency to hinder subsequent clinical translation 23,24,25