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And that doesnt even take into account cardiovascular disease and diabetes

What factors of GLP-1 coverage drive up premiums Using data from MarketScan and research by Blue Health Intelligence (BHI), the EBRI report models how GLP-1 coverage could affect employer-sponsored insurance premiums, exploring several scenarios based on: Drug pricing Net costs range from $617 to $766 per 30-day supply Patient adherence Perfect adherence leads to higher premiums due to sustained drug use Eligibility criteria Including overweight individuals with at least one weight-related condition significantly increases cost burden Cost-sharing Cost-sharing structures such as $90 copays help but dont eliminate increases Usage is growing More than 57 million privately insured adults qualify for GLP-1 drugs, like Ozempic and Wegovy

Also, experiments conducted in primary islet cells have shown that -arrestin1 restricts the insulin secretion response to GLP1R activation, but not to GIPR activation or tirzepatide

believe that the decrease of GLP-1 in obese subjects may be related to increased plasma non-esterified fatty acids (NEFA)