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Nausea, diarrhea, vomiting, and constipation commonly occur within the first month of starting.[ref][ref] Note that for many people, gastrointestinal side effects seem to be dose-related

In obese mice, combining ERR activation with dietary control yields additive improvements in fat mass and hepatic features, suggesting compatibility with lifestyle or other pharmacological interventions

GLP-1R activation is associated with decreased activity of the NF-B pathway [42], which orchestrates a wide range of stress-related inflammatory responses and controls the growth, survival, and development of many cell types

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