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The Standard 16-Week Semaglutide Titration Schedule Most semaglutide protocols follow a predictable escalation pattern: Week 14 uses 0.25 mg weekly, Week 58 increases to 0.5 mg weekly, Week 912 moves to 1.0 mg weekly, and Week 1316 reaches 1.7 mg weekly, with Week 17+ at the target maintenance dose of 2.4 mg weekly