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30 Three of the four RCTs of B12 alone used oral B12 (1000 g per day) and one used i.m

Potential Side Effects and Warnings Common Side Effects These are reported by at least Nausea Diarrhea Vomiting Constipation Abdominal pain Dyspepsia (indigestion) Gastroesophageal reflux disease (heartburn) Injection site reactions Fatigue Hypersensitivity reactions Hair loss As you can see, the gut is most often affected (gastrointestinal adverse reactions), but these are usually If, however, any of these side effects are severe, dont settle, or are impacting your life, you should ask for medical advice

Intestinal surgery and stomach stapling can cause malabsorption, and the elderly are more prone to deficiency as well

Sleep disturbance, cognitive decline, and dementia: a review