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Liraglutide, semaglutide, and more recently tirzepatide, have been tested in various animal models of obesity, type 1 diabetes and T2D, osteoporosis, and diabetes-induced osteoporosis

PYY can regulate the expression of pancreatic beta cell apoptosis-related genes, promote beta cell proliferation, and protect beta cell function and reserve by inhibiting insulin oversecretion, thus preventing beta cell dysfunction

Primarily utilized in treating type 2 diabetes, GLP-1s mimic the actions of glucagon-like peptides that are naturally secreted by the ileum, olfactory bulb, and hindbrain and exhibit a myriad of metabolic functions

Analytical-grade monoclonal antibodies against -tubulin, Bax, Bcl-2, caspase-3, and Iba-1, as well as HRP-conjugated secondary antibodies, were obtained from Abcam (Cambridge, United Kingdom)