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The extracellular matrix provides structural support for tissues while regulating communication between cells and influencing how tissues are organised and maintained

Use of fresh blood samples would be most appropriate for point-of-care diagnostic applications

Therefore, there is still the need for the discovery and/or development of a drug candidate characterized by at least a comparable pain-relieving effect to opioids but with a much better safety profile in terms of expected adverse reactions

2009), they are also implicated in a variety of other physiological processes, including stress response, respiration, food intake, gastrointestinal motility, as well as endocrine and immune responses (Le Merrer et al