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While these drugs have become very popular, they are not without risks

Use of GLP-1 drugs for weight loss is common (as much as 12% of the population), but long-term adherence to the medications has been reported to be poor

Research suggests that berberine may: Improve insulin sensitivity Support healthy glucose metabolism Influence gut microbiota composition Enhance pathways involved in GLP-1 secretion Other ingredients that may support GLP-1 activity include: Prebiotic fibers like inulin Polyphenols from green tea Omega-3 fatty acids These nutrients work by supporting metabolic processes linked to increase GLP-1 naturally, rather than directly mimicking the hormone

Primary Care Diabetes & Metabolism Endocrinology Family Medicine Charleston, SC Patrick O'Neil, Ph.D