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While the decision to continue other oral antidiabetic drugs or GLP-1 receptor agonists should be made on an individualized basis, they may afford better postprandial control and reduce the insulin requirements, which in turn is associated with a lesser weight gain

The main adverse effects described in clinical trials employing tirzepatide were gastrointestinal, such as nausea, diarrhea, decreased appetite, delayed gastric emptying, vomiting, acid reflux, and constipation (57)