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Interestingly, activation of NRF2 regulates iron-related genes such as FTH1 , FTL1 , SLC40A1 , ABCB6 , and HMOX1 , which in turn promotes the synthesis of GSH synthesis, limits ROS production, and regenerates NADPH [64, 66]

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doi:10.1074/jbc.M805586200, PMID: 18990698 Borutaite V, Brown GC (2007) Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state