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Currently, plasma ACs profiling has commonly been used for the diagnosis of mitochondrial fatty acid oxidation deficiencies (mFAODs) in neonates and is an important biomarker of mitochondrial dysfunction ( Peroxisome proliferator-activated receptor alpha (PPAR) is a transcription factor that regulates transcription by binding to the PPAR response elements of several genes, including genes related to mitochondrial and peroxisomal -FAO (Zhao et al., 2017)and limits hepatic steatosis associated with high-fat diet, T2DM and obesity-related insulin resistance ( In this study, we propose to investigate the possible mechanism of VPA-induced disorder of ACs profiles, relative gene expression, including ACs transport and -FAO enzyme was tested at the cellular and animal levels to explore the candidate biomarkers for VPA-induced abnormal liver function

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Routes studied SubQ injection is most common