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[82] reported that unphosphorylated STAT3 (U-STAT3) could bind to several promoters which do not contain the binding site for pSTAT3, e.g., IL-6 and RANTES genes, in human HME1 cells

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However, only the injectable form has been available because peptide drugs are usually not suitable for administration via the oral route, as they present low oral bioavailability, are inactivated when they reach the gastrointestinal tract, and have low rates of diffusion into the cell [31, 32]

Acta Neurol Scand 69:186189 Rivelli M, El-Mallakh RS, Nelson WH (1988) Carbamazepine-associated asterixis and hyperammonemia