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CYP2D6, MDMA, and methamphetamine: background considerations CYP2D6 accounts for only a small percentage of total hepatic cytochrome P450 (12%), yet it is responsible for the metabolism of approximately 2030% of marketed pharmaceuticals, including tricyclic antidepressants, selective serotonin reuptake inhibitor antidepressants, opioids, and antipsychotic, antiemetic, antiarrhythmic, and amphetamine-like drugs (Ingelman-Sundberg, 2005)

The FDA withdrew approval for Geref in 2008 for commercial reasons unrelated to safety, meaning the molecule has never carried an active pediatric labeling claim since then

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SpO2 is often lowered in COVID-19, particularly in more severe instances and in the presence of CCTAs [95, 96], and both CCTAs and decreased SpO2 are highly related to immunological activation [25]