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In this review, the GLP-1/GLP-1R system implicated in diabetic endothelial dysfunction and related autophagy mechanism underlying the pathogenesis of diabetic vascular complications are briefly presented

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Weeks 1-6 Loading Phase Topical: twice-daily application over treatment zones Injection: 250500 g sub-Q, 35 weekly Weekly RN check-ins to track skin metrics, pain scores, and hair density photos

The trial also met all key secondary endpoints, including improvements in waist circumference , systolic blood pressure, triglycerides, non-HDL cholesterol, LDL cholesterol, and serum uric acid