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At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial

Women following the retatrutide dose schedule may benefit from planning dose escalations to avoid the luteal phase of their menstrual cycle, when GI sensitivity tends to be highest

The Epac2 arm activates PLC epsilon through Rap1 and this also leads to increased intracellular Ca 2+ ( Figure 3 )

2025 Jul 25;14(15):5269