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Brain sections from patients who died from COVID-19 showed fibrinogen extravasation and coagulation system dysregulation 21,22 , while mouse models revealed changes in blood vessel morphology with the appearance of string vessels, that is, pathological ghost vessels without endothelial cells 28

This imbalance leads to uncontrolled NE activity, subsequently causing early-onset emphysema ( Acute respiratory distress syndrome (ARDS) involves neutrophil accumulation in alveolar spaces and NSP release, causing alveolar-capillary barrier damage and exacerbated inflammatory responses ( Autoimmune diseases present additional possibilities

Safety data are lacking

This suggests that leptin is released in response to inflammation and that leptin itself enhances inflammation [168,195,196,199]