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however, these medications often turn the acute inflammation and rapid progression of renal disease into chronic inflammation and slow, but do not stop, the still inevitable progression of end-stage renal disease

In a head-to-head open-label trial reported in February 2026, average weight loss at 84 weeks favored tirzepatide, and the sponsor noted CagriSema did not meet its prespecified non-inferiority target against tirzepatide