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The clinical significance was highlighted by Lilly's leadership: "Obesity is a chronic, progressive disease, and sustaining weight loss remains a significant challenge for many," said Kenneth Custer , Ph.D., executive vice president and president, Lilly Cardiometabolic Health

To mitigate these effects, providers often recommend taking oral medications with plenty of water or a small amount of food, unless otherwise directed

Staying hydrated, taking medication at consistent times, and ginger or peppermint supplements help many patients manage gastrointestinal symptoms without stopping treatment