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This is due to cumulative damage to mitochondrial DNA which would otherwise have been reduced by glutathiones antioxidant activity and protective effects

During this phase, monitor GI symptoms daily

Common examples include fatigue or low energy with normal blood results, brain fog or reduced concentration without confirmed vitamin B12 deficiency, stress-related exhaustion or burnout, increased metabolic demand such as during illness recovery, high workload, or intense training, restrictive or inconsistent dietary intake, or suspected poor oral absorption despite normal serum levels

What is not simple is the dose, because P-21 has no human trial and therefore no validated figure to aim for