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Invading white blood cells secrete pro-inflammatory factors, which trigger reactive response of neural parenchymal cells, most notably reactive astrogliosis and microgliosis

RAAS-inhibition with captopril mitigated RN in a randomized controlled trial in patients after 14 Gy TBI in 9 fractions with kidney shielding yielding a total dose of 9.8 Gy in preparation for BMT

12 Because only 1 patient had a baseline height SDS greater than 3, based on height alone, the patient population is closely reflective of eligible Canadian patients

Chaudhari P, Satarker S, Thomas R, Theruveethi N, Ghate V, Nampoothiri M, et al