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Given that TNF- and IL6 have been demonstrated to enhance ceramide production [36, 37], we propose that senescent granulosa cells may contribute to ceramide accumulation through autocrine or paracrine secretion of TNF- and IL6

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True metabolic healing that lasts requires deeper work that targets: Insulin resistance at the cellular level Chronic inflammation that affects ovulation and egg quality Nutrient deficiencies like zinc, magnesium, vitamin D, and choline Hormone signaling issues , including leptin resistance, estrogen dominance, or HPA axis dysregulation Without resolving these, even if your weight drops, your body may still perceive pregnancy as unsafe

Tumor necrosis factor-alpha downregulates the voltage gated outward K + current in cultured neonatal rat cardiomyocytes: a possible cause of electrical remodeling in diseased hearts