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32, 33 Although numerous stimulants can affect PSCs including activation of some G-protein-coupled receptors (PGE2, angiotensin, CCK-A, CCK-B), 34, 35, 36, 37, 38, 39 it is unknown if GLP-1R occurs on PSC either in normal pancreas or pancreatic disease states or, whether PSCs are activated in AP or CP, or if it does occur, whether the GLP-1R agonists affect the PSC signaling cascade, growth or ability to release inflammatory mediators

Pulmonary hypertension is high blood pressure in the lungs, which can be life-threatening

Clinical context: GLP-1/GIP receptor agonists now dominate the peptide market and accounted for the majority share of therapy-related value recently, reflecting clinical adoption and investment in these drugs