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Materials and Methods Animal Study New Zealand female white rabbits (12 weeks old, weighing 3.5 0.2 kg, N=40) were obtained from Koatech (Seoul, Korea)

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The OCTN subclade, comprised of OCTN1 (SLC22A4) and OCTN2, are a distinct subgroup of OCTs that primarily catalyse the uptake of the zwitterionic metabolites ergothioneine 13 and carnitine respectively, but are also capable of transporting cations such as tetraethylammonium (TEA) 14,15 indicating a potential dual transport function 15,16

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