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Besides, doxorubicin-loaded manganese dioxide nanoparticles (MnO 2 ) encapsulated in vitamin D 3 -inserted lipid-mixed neutrophil membranes to form the nanoplatform NED@MnO 2 -DOX can activate and enhance immune responses associated with the cGAS-STING pathway, such as promoting the secretion of type I interferon- and pro-inflammatory cytokines, facilitating DCs maturation and promoting infiltration of CD8 + T cells into tumor tissues (233)

Li GG, et al

Atezolizumab with enzalutamide versus enzalutamide alone in metastatic castration-resistant prostate cancer: a randomized phase 3 trial