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BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide consisting of 15 amino acids, with the primary sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Derived from a highly stable, naturally occurring protein fragment isolated from gastric juice, this peptide is engineered via solid-phase synthesis for structural stability in laboratory environments
Combined with differences in shape complementarity and the substitution of CDK11 G579 with an alanine in CDK2, this helps explain the comparably poor ability of OTS964 to inhibit CDK2 (Supplementary Fig
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DOI: 10.1038/s41598-024-66034-9
Heinzerling L, Mari A, Bergmann KC, et al
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