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The pentose phosphate pathway can also function as an anabolic pathway that utilizes the six carbons of glucose to generate five carbon sugars, particularly ribose-5-phosphate (R5P) that is required for purine and pyrimidine nucleotide biosynthesis

From a clinical standpoint, the results of this study are very encouraging but should be implemented with cautious, the majority of studies identified in our study was of small or moderate size and conducted in a single center by almost one group in Catania, Italy