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When treating autoimmune diseases, combinations of drugs are used, such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, antibodies and small molecule drugs (DMARDs) [16]
They are not a recommendation, and there is no modern, well-powered, FDA-recognized human trial that establishes a clinically validated dose
Continuous daily dosing beyond 72 hours may trigger c-Met receptor downregulation and internalization, reducing the compound's effectivenessa concern that favors intermittent protocols for extended research timelines
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