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Its concentration decreases with age: from 200 ng/mL at age 20 to 80 ng/mL at age 60

6, September: 3083-3092, 2018 Patients and Methods: This study included 30 female patients with melasma who were selected among those attending the Outpatient Clinic of Dermatology and Venereology De- partment, Tanta University Hospitals during the period between December, 2015 and February, 2017