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Ackerstaff, E., Gimi, B., Artemov, D

MLN4924, a small molecule inhibitor of neddylation, increases glutamine uptake in breast cancer cells by inactivating the CRL3-SPOP E3 ligase, leading to the ASCT2 upregulation

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6 Redox-endocrine triad: mechanistic intersections of vitamin D, MI, and melatonin 6.1 Shared molecular targets: OS reduction, mitochondrial stabilization, and anti-inflammatory signaling The integral pathophysiology of PCOS is linked to chronic OS, mitochondrial dysfunction, and subclinical inflammation, all of which fuel endocrine and metabolic disturbances (158)