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Many authors have proposed that nicotine receptors play a role in the aforementioned pathologies, but the influence of OS has only recently become of interest [7]

The role of sentinel lymph node biopsy remains unclear in this population.[260] Current guidelines recommend that individuals with EB and unresectable SCC be treated with radiation therapy, but the dose may need to be given in smaller fractions in order to decrease the risk of skin desquamation