In its ATTAIN-1 trial, orforglipron produced an average weight loss of about 12% of total body weight, with some patients losing up to 15%
Glucagon agonism (retatrutide only) is where it gets genuinely interesting
Catalpol ameliorates LPS-induced endometritis by inhibiting inflammation and TLR4/NF-B signaling

ingredients: aqua/water/eau, cyclopentasiloxane, bis-peg-18 methyl ether dimethyl silane, glycerin, butylene glycol, butyrospermum parkii (shea) butter, glyceryl stearate, peg-100 stearate, cetearyl alcohol, cetyl alcohol, limnanthes alba (meadowfoam) seed oil, phenoxyethanol, stearic acid, tocopheryl acetate, salvia hispanica seed oil, panthenol, parfum/fragrance, acrylates/c10-30 alkyl acrylate crosspolymer, linalool, bht, ascorbyl glucoside, disodium edta, sodium hydroxide, peg-8, tocopherol, sodium hyaluronate, lecithin, alcohol denat., geraniol, polyglyceryl-3 diisostearate, pantolactone, ascorbyl palmitate, citronellol, camellia sinensis leaf extract, coffea arabica (coffee) seed extract, pongamia pinnata seed extract, benzyl benzoate, limonene, ascorbic acid, angelica archangelica root extract, citrus aurantium amara (bitter orange) peel extract, maltodextrin, citric acid, magnesium aluminum silicate, xanthan gum, caprylyl glycol, sclerotium gum, sorbic acid, fd&c yellow no