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The immunogenic potential of nanocarriers can attenuate therapeutic efficacy [113], while protein- or peptide-based vectors are susceptible to enzymatic degradation and premature drug release, leading to diminished on-target effects and heightened off-target risks

In contrast, our analysis provided a more in-depth exploration of this relationship and further incorporated drug-target MR analyses to evaluate the potential therapeutic implications of GLP-1RAs, a class of antidiabetic drugs, for individuals with SA

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10.1002/ALZ.053235 206 ZhangH.ZhouL.DaviesK