GI disorders were the most common AE in the semaglutide groups in these studies, including nausea (14% to 58% of semaglutide patients versus 5% to 22% of placebo patients) and diarrhea (14% to 36% of semaglutide patients versus 7% to 22% of placebo patients)
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The results demonstrated a significant reduction in composite renal outcomes, largely driven by the improvements in glycemic control and reductions in SBP, which in turn led to a decreased risk of eGFR decline and cardiovascular events [110]
