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However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]

2018;24(9a Suppl):S1429

Moreover, curcumin is prone to solvolysis, auto-oxidation, and photodegradation, requiring strict storage conditions (Kotha and Luthria, 2019), while rosmarinic acid is easily metabolized by intestinal microbial esterases (Calabrese et al., 2024)

Other diets, including the low FODMAP diet, have not been shown to eliminate SIBO, but may help your symptoms if you have co-occurring IBS