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Other important factors include: Duration of diabetes : Longer disease duration is associated with greater beta-cell dysfunction, which may reduce the incretin-based response to DPP-4 inhibition Residual beta-cell function : As DPP-4 inhibitors rely on stimulating endogenous insulin secretion, patients with significantly impaired beta-cell reserve may respond less well Adherence to treatment : Consistent daily dosing is essential

King, 2012

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L-arginine is found in protein-rich foods like meat, poultry, fish, soy, and legumes