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Beta-actin served as the housekeeping gene

Phase I detox chemically transforms these compounds to a less toxic form making them water soluble and ready for Phase II

Mechanistic pathways associated with acetaminophen-induced hepatotoxicity APAP is rapidly absorbed and extensively metabolized upon entering the liver, with 8590% conjugated with glucuronic acid or sulfate by the enzymes uridine diphosphate-glucuronosyltransferase and sulfotransferase and subsequently eliminated

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