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doi:10.2170/physiolsci.rp006208

It has been demonstrated that in some cases of oral mucosal melanoma, there is loss of the integrity of the melanosomal membrane with leakage into the cytoplasm and nucleoplasm of the melanocytes, of toxic melanin particles, intermediates of melanogenesis and reactive oxygen species, with consequent DNA damage and increase in the risk of genetic mutations [59]

Two metabolites, allopregnanolone and pregnanolone, positively modulate that receptor while two other metabolites, isoallopregnanolone and epipregnanolone, have the opposite effect