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In January 2025, a warning for severe gastrointestinal adverse reactions was added

By correcting for possible imbalances, we aimed at reducing infection-related gastric pathologies

The molecular mechanisms by which TMAO exacerbates renal insufficiency, include the activation of inflammatory pathways, induction of oxidative stress, SMAD signaling, and impairment of endothelial cell function [12, 38]

[PubMed: 2753972] 507