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There was a progressive decrease of the proportion of patients at target for each 0.5% increase in baseline HbA1c, ranging from 57.8% for HbA1c 7.5% to 20.8% for HbA1c 10% (p for trend 9.0% with no further decrease, whereas for non-insulin drugs the relationship was continuous without any evidence of plateau 5

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These cells, derived from bone marrow, can differentiate into mature endothelial cells, contributing to vascular regeneration, particularly in response to injury or ischemia

Which means in those disease states, and aging, this metabolic leak gets worse