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Clinical observations from practitioners using microdosed GLP-1 in Hashimoto patients report improvements in thyroid antibody levels (TPO and thyroglobulin antibodies) and reductions in thyroid-related fatigue
Hepatic function plays a minimal role in GLP-1 elimination, as these medications are primarily degraded by proteolytic enzymes throughout the body rather than hepatic metabolism
It has a short half-life in blood of 1.5-3 min due to a high clearance but also activates afferent nerve endings directly before entering the blood
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