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There was also a significant reduction of immunoreactivity in STZ-des rats versus STZ-veh rats [4]

Autophagy-lysosomal pathway impairment induces molecular signatures, including elevated LC3-II expression with concomitant LC3-II/LC3-I ratio upregulation, p62 accumulation and reduced histone D levels (125)

The use of MRI spectroscopy helps in the assessment of the fatty infiltration of the liver through the fat to water ratio of the liver, and therefore it is a specific and precise method of diagnosis of MASLD especially in patients without diabetes (85)

Kidney disease