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Chronic, low-grade inflammation plays a crucial role in mediating both hepatic and most extrahepatic complications of MASLD

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For instance, weight loss and improved insulin sensitivity may alter the bodys hormonal milieu, potentially affecting the metabolism and effectiveness of administered hormones like estrogen, progesterone, and testosterone

The clinical concern is not about drug testing but about gastroparesis risk: semaglutide slows gastric emptying, which can increase aspiration risk under general anesthesia if fasting protocols are not appropriately extended