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Should not be consumed by pregnant or lactating women and children below 18 years old

Mental health considerations when stopping GLP-1 medications The psychological dimension of getting off GLP-1 medications rarely gets the attention it deserves

Interestingly, GLP-1 is also known to decrease the rewarding effects of food intake by interacting with parts of the mesolimbic dopamine system such as the ventral tegmental area (VTA), nucleus accumbens (NAc) [34], and also GABAergic circuits in the laterodorsal tegmental nucleus (LDTg) [35], which makes brain GLP-1R signaling a promising target for the treatment of alcohol and cocaine abuse disorders [36, 37]