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Similarly, if cationic resins are severely contaminated by iron or heavy metals such that their exchange capacity cannot be restored, or if the resin structure has been compromised by strong oxidizers (causing the resin to soften and fracture), regeneration cannot restore performance, and replacement is the only viable option

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Those are the treatments discussed above, which are nonsurgical, and are mostly focused on lasers, microneedling, injections, medications, and supplements