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The second coupling can also be carried out with excess of the second antibody, and leftover second antibody can easily be removed due to its reactive SpyTag

The iron-overload state commonly observed in AD brains exacerbates neuronal oxidative damage and, through the release of pro-inflammatory mediators and activation of immune cells, contributes to the structural disruption of the BBB

Compared to UBE2m RK, fatty acid metabolism and mitochondrial respiration were inhibited after re-expression of UBE2m WT, and the suppressed OCR was rescued significantly after treatment with MLN4924 (Figs