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In the SURPASS-2 trial (published in The New England Journal of Medicine in 2021), tirzepatide at 5, 10, and 15 mg was compared with semaglutide 1 mg in 1,879 adults with type 2 diabetes on metformin over 40 weeks

Reduced glutathione (GSH) and oxidized glutathione (GSSG) form an interconnected redox couple reflecting peroxide detoxification, thiol chemistry, and reducing capacity

The following measures can help manage injection site reactions: Applying a cold compress to the area, such as an ice pack, may help to reduce swelling